Safety of infant exposure to antidepressants and benzodiazepines through breastfeeding. The transfer of drugs and therapeutics into human breast milk: An update on selected topics. Postpartum contraception: Initiation and methods. Docusate (Colace, Phillips' Stool Softener, others).Talk to your health care provider before taking this type of birth control while breastfeeding. Researchers don't have a final answer about whether combination contraceptives containing estrogen and progestin affect milk production. Combination contraceptives containing estrogen and progestin - discuss this option with your provider.Progestin-only contraceptives, also known as the minipill.Medications containing pseudoephedrine (Sudafed, Zyrtec D) - use with caution because pseudoephedrine can decrease milk supply.Penicillins, such as amoxicillin and ampicillin.Clotrimazole (Mycelex, Lotrimin AF) - apply minimal amount.Miconazole (Monistat 3, Monistat 7, others) - apply minimal amount. Use is not recommended and a decision should be made to discontinue breastfeeding or discontinue the drug, taking into account the importance of the drug to the mother.Ĭomments: Infants exposed to this drug through breast milk should be closely monitored for excess sedation and respiratory depression withdrawal symptoms can occur when maternal administration of hydrocodone is stopped or breastfeeding is stopped. Hydrocodone is metabolized to 6 active metabolites including hydromorphone. There are no studies describing drug levels of extended-release hydrocodone or its metabolites in breast milk. Once a mother's milk comes in, it is best to provide pain control with a nonnarcotic analgesic. Maternal use of oral narcotics during breastfeeding can cause infant drowsiness, central nervous system depression, and even death. See references Hydrocodone Breastfeeding Warnings Pregnancy categories A, B, C, D, and X are being phased out. US FDA pregnancy category Not Assigned: The US FDA has amended the pregnancy labeling rule for prescription drug products to require labeling that includes a summary of risk, a discussion of the data supporting that summary, and relevant information to help health care providers make prescribing decisions and counsel women about the use of drugs during pregnancy. There are no controlled data in human pregnancy.Ĭhronic opioid use may cause reduced fertility in males and females it is unknown whether these effects on fertility are reversible. Prolonged use of opioid analgesics during pregnancy for medical or nonmedical purposes may cause neonatal opioid withdrawal syndrome. No fetal malformations were observed in rats and rabbits at doses approximately 2 (rats) and 10 (rabbits) times a human dose of 100 mg/day. Additionally, increases in the number of umbilical hernias, irregularly shaped bones, and delays in fetal skeletal maturation were observed in the study at doses 15 times the human dose of 100 mg/day. Reduced fetal weights were observed in rabbits given this drug during the period of organogenesis at doses equivalent to 5 times the human dose of 100 mg/day. Reduced nursing behavior and decreased body weights were observed at 2 times the human dose. Rats administered this drug during gestation and lactation showed increases in stillborn pups and decreases in pup survival at doses equivalent to the human dose of 100 mg/day. Long-acting opioids should not be used during and immediately prior to labor, when short acting analgesics or other analgesic techniques are more appropriate. Women should be advised of the risk of neonatal abstinence syndrome and ensure that appropriate treatment will be available. Risk Summary: Based on animal data, may cause fetal harm prolonged maternal use of opioids during pregnancy may cause neonatal opioid withdrawal syndrome. Hydrocodone is also known as: Hysingla ER, Vantrela ER, Zohydro ER Hydrocodone Pregnancy and Breastfeeding Warnings
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